C1-esterase inhibitor, human

Adult: Treatment of acute attacks: As 50 international units/mL: 20 international units/kg via slow IV inj at 4 mL/min. As 100 international units/mL: 1,000 international units via slow IV inj at 1 mL/min, given at the 1st sign of the onset of the attack. Administer a 2nd dose of 1,000 international units if there is no adequate response after 1 hour; if the treatment is intended for acute laryngeal angioedema attacks or there is a delay in treatment initiation, the 2nd dose may be given sooner than 1 hour. Prophylaxis of angioedema attacks: As 100 international units/mL: 1,000 international units via slow IV inj at 1 mL/min every 3 or 4 days. If there is inadequate response, may consider giving 2,000 international units (Max: 80 international units/kg) every 3 or 4 days based on individual patient response. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Treatment of acute attacks: As 50 international units/mL: Same as adult dose. As 100 international units/mL: 2-11 years weighing 10-25 kg: 500 international units via slow IV inj at 1 mL/min, given at the 1st sign of the onset of the attack. Administer 2nd dose of 500 international units if there is no adequate response after 1 hour; >25 kg: 1,000 international units via slow IV inj at 1 mL/min, given at the 1st sign of the onset of the attack. Administer a 2nd dose of 1,000 international units if there is no adequate response after 1 hour. 12-17 years Same as adult dose. Prophylaxis of angioedema attacks: As 100 international units/mL: 6-11 years 500 international units via slow IV inj at 1 mL/min every 3- or 4 days. If there is inadequate response, may consider giving 1,000 international units every 3 or 4 days based on individual patient response. 12-17 years Same as adult dose. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Adult: As 50 international units/mL: 1,000 international units via slow IV inj at 4 mL/min, given <6 hours before surgical procedure. As 100 international units/mL: 1,000 international units via slow IV inj at 1 mL/min, given within 24 hours before surgical procedure. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: As 50 international units/mL: 15-30 international units/kg via slow IV inj at 4 mL/min, given <6 hours before surgical procedure. As 100 international units/mL: 2-11 years weighing 10-25 kg: 500 international units via slow IV inj at 1 mL/min, given within 24 hours before surgical procedure; >25 kg: Same as adult dose. 12-17 years Same as adult dose. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Adult: As 500 international units/mL: 60 international units/kg twice weekly (e.g. every 3-4 days) via SC inj, preferably at the stomach. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: As 500 international units/mL: ≥8 years Same as adult dose. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).